Dear Dr. Booth
We are submitting our work titled “Extracellular ATP, ADP or adenosine stimulation induces gene expression in skeletal miotubes” to the Journal of Biological Chemistry. The work’s authors are Lic. Rodrigo Fernández, PhD Sonia Buvinic and PhD Enrique Jaimovich, all members of the Muscle Cellular Physiology Laboratory from the University of Chile. Our research was designated to increase our understanding of the slow calcium signaling pathway in muscle cells, through the identification of some extracellular receptors involved on it, which activation leads to gene expression.
We showed that specific activation of P2Y1 and adenosine receptors can resemble some of the genetic expression induced by contraction of muscle cells, probably activating the slow calcium signaling pathway. It is so important because if we unravel the complete pathway, then we will be able to found the better exercise protocol that leads to its activation and the gene expression derived of it, so we can prescribe this exercise to the people who precisely need to express that proteins. On the other hand, there will be the possibility to design pharmaceutical agents that can activate the pathway for those people who can not exercise.
The article has not been submitted for publication elsewhere, and there are not conflict of interests.
Sincerely
Lic. Rodrigo Fernández
MSc student at the University of Chile
For contact write to rodrigo@med.uchile.cl
Hi Rodrigo,
ResponderEliminarHere go some suggestions to write the last version of your letter:
1. Erase "to the journal" and say "to xxxxx".
2, I would change the phrasing of "The work´s authors..." by "the article is authored by xxxx etc".
3. Lic. in English corresponds to BA or BSc, but I doubt it whether it is necessary to mention. Only when you hold a PhD, you normally write it explicitely.
4. The next paragraphs are a little confusing and have several grammar mistakes. I recommned you to take a look again and follow this structure;
a. OK say in general words what the research describes...
b. Next paragraph, start with what is unknown and then talk about your results (to find, not found, avoid using words like "so important"). I think the sentence "On the other hand....etc" is unnecessary in this letter.
5. Erase Lic. again.
6. Are you the corresponding author? If so, you have to say so.
Hope these suggestions are helpful.
Best,
Claudia